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FDA-Approved Combination Therapy

Pegasys + Copegus (peginterferon alfa-2a + ribavirin)

PegIntron + Rebetol (peginterferon alfa-2b + ribavirin)

Roferon A + Ribavirin (Standard interferon alfa-2a + ribavirin)

Intron A + Rebetol (Standard Interferon alfa-2b + ribavirin)


Pegasys + Copegus
peginterferon alfa-2a + Copegus (ribavirin)

PEGASYS Medication Guide

Pegasys Product Information

Copegus Medication Guide

Copegus Product Information

Articles on Pegasys + Copegus
IDEAL Researchers Look at Predictors of Response to Pegylated Interferon plus Ribavirin, including Race/ethnicity and Anemia - 11/07/2008
Safety and antiviral activity of BI 201335, a new HCV NS3 protease inhibitor, in treatment-naïve patients with chronic hepatitis C genotype 1 infection given as monotherapy and in combination with peginterferon alfa-2a (P) and ribavirin (R) - 11/05/2008
Safety and antiviral activity of BI 201335, a new HCV NS3 protease inhibitor, in combination therapy with peginterferon alfa-2a (P) and ribavirin (R) for 28 days in P+R treatment-experienced patients with chronic hepatitis C genotype 1 infection - 11/05/2008
Hematologic Safety Data From the IDEAL Trial: Neutropenia, Anemia, and Thrombocytopenia Profiles of Peginterferon alfa/Ribavirin - 11/05/2008
Treatment-Related Anemia Is Associated With Higher SVR Rates Among Persons Treated With Peginterferon (PEG)/Ribavirin (RBV): Results From the IDEAL Study - 11/05/2008
Response to Pegylated Interferon plus Ribavirin in Asian Patients with Genotype 1 Chronic Hepatitis C - 10/21/2008
Pegylated Interferon plus Ribavirin Produces High Sustained Response Rate in HBV-HCV Coinfected Individuals - 10/17/08
24 Weeks of Pegylated Interferon plus Ribavirin May Be Sufficient for Selected Genotype 1/4 Chronic Hepatitis C Patients with Rapid Response - 10/14/08
Individuals with HCV Genotype 6 Respond Well to Pegylated Interferon plus Ribavirin - 10/14/08
Higher Doses of Pegylated Interferon and Ribavirin May Increase Sustained Response Rates in Hard-to-Treat Patients with Chronic Hepatitis C - 10/10/08
Sustained Virological Response to Pegylated Interferon plus Ribavirin for Chronic Hepatitis C Does Not Always Prevent Hepatocellular Carcinoma - 10/10/08
Genetic Variation Linked to Sustained Response to Pegylated Interferon plus Ribavirin in HALT-C Trial - 9/09/2008
Insulin-sensitizing Agent Pioglitazone (Actos) Did Not Improve Response to Re-treatment with Pegylated Interferon plus Ribavirin - 8/29/2008
Are HIV Positive People More Likely to Relapse after Completion of Hepatitis C Treatment with Pegylated Interferon plus Ribavirin - 8/19/2008
Body Weight Affects Relapse Rates in Latinos with Genotype 2/3 Hepatitis C Treated with Pegylated Interferon Alfa-2a (Pegasys) plus Ribavirin - 8/12/2008
Eight Weeks of Pegylated Interferon plus Ribavirin for Genotype 2 Chronic HCV Patients with Rapid Virological Response (RVR) - 8/05/2008
Telaprevir plus Pegylated Interferon and Ribavirin Produces Rapid Response and Is Well Tolerated in 28-day Study - 7/22/08
Comparison of the Pegylated Interferons Pegasys and PegIntron for Treatment of Chronic Hepatitis C: Analysis of 16 Randomized Trials - 7/18/08
12- Versus 24-week Treatment with Pegylated Interferon plus Ribavirin for Genotype 2 or 3 Chronic Hepatitis C Patients - 7/11/08
Studies Explore Lower Doses of Pegylated Interferon and Ribavirin for People with Hepatitis C Virus Genotypes 2 or 3 - 7/08/08
European Commission Approves Shorter 16-week Course of Pegasys plus Ribavirin for Rapid Responders with HCV Genotypes 2 or 3 and Low Viral Load - 7/04/08
Pegylated Interferon Alfa-2a (Pegasys) Continues to Suppress HBV, but Adding Adefovir (Hepsera) Provides No Extra Benefit in PEG for B Trial - 6/03/08
Platelet Count Is a Strong Predictor of Sustained Response to Pegylated Interferon/ribavirin in Prior Non-Responders (EPIC 3) - 5/20/08
Rapid Virologic Response to Peginterferon alfa and Ribavirin Treatment of Chronic Hepatitis C Predicts Sustained Virologic Response and Relapse - 5/20/08
Amino Acid Substitutions in HCV Core Region Predict Poor Response to Pegylated Interferon/ribavirin in Genotype 1b Patients - 5/20/08
Pegylated Interferon plus Ribavirin Is Effective for Patients with HCV-HBV Coinfection - 5/09/08
Factors Predicting Relapse in Patients with Genotype 2/3 HCV Treated with Pegylated Interferon plus Ribavirin - 5/06/08
Factors Predicting Relapse in Patients with Genotype 2/3 HCV Treated with Pegylated Interferon plus Ribavirin - 5/06/08
Cyclophilin Inhibitor Debio 025 Exhibits Additive Activity against HCV in Combination with Pegylated Interferon - 5/06/08
IDEAL Study Finds Higher End-of-treatment Response with Pegasys, but Lower Relapse Rate with PegIntron - 5/02/08
Milk Thistle (Silibinin) Shows Potent Antiviral Activity in Hepatitis C Patients Who Are Non-responders to Pegylated Interferon/Ribavirin - 5/02/08
R7128 Demonstrates Potent Anti-HCV Activity in Combination with Pegylated Interferon/Ribavirin; Ongoing Trial to be Expanded - 4/29/08
Large HCV RNA Decrease Reduces Adverse Clinical Outcomes, but Pegylated Interferon Maintenance Adds Little Benefit (HALT-C) - 4/29/08
Pegylated Interferon Maintenance Demonstrates Benefits for Hepatitis C Patients with Portal Hypertension - 4/29/08
HCV Polymerase Inhibitor R1626 Produces Good Response with Pegylated Interferon/Ribavirin and Has High Barrier to Resistance - 4/29/08

How Ideal Is the IDEAL Trial?

 

PegIntron + Rebetol
peginterferon alfa-2b + Rebetol (ribavirin)

PEG-INTRON® Prescribing Information

REBETOL® Prescribing Information

Articles on PegIntron + Rebetol
IDEAL Researchers Look at Predictors of Response to Pegylated Interferon plus Ribavirin, including Race/ethnicity and Anemia - 11/07/2008
Boceprevir Plus Peginterferon alfa-2b/Ribavirin for Treatment of Genotype 1 Chronic Hepatitis C in Previously Untreated Patients: Interim Results from the HCV SPRINT-1 Study - 11/05/2008
Probability of Sustained Virologic Response (SVR) Is Associated With the Magnitude of HCV RNA Reduction at Week 4 of Treatment With Peginterferon (PEG) Plus Ribavirin (RBV): Results of the IDEAL Trial - 11/05/2008
Hematologic Safety Data From the IDEAL Trial: Neutropenia, Anemia, and Thrombocytopenia Profiles of Peginterferon alfa/Ribavirin - 11/05/2008
Treatment-Related Anemia Is Associated With Higher SVR Rates Among Persons Treated With Peginterferon (PEG)/Ribavirin (RBV): Results From the - 11/05/2008
Response to Pegylated Interferon plus Ribavirin in Asian Patients with Genotype 1 Chronic Hepatitis C - 10/21/2008
Pegylated Interferon plus Ribavirin Produces High Sustained Response Rate in HBV-HCV Coinfected Individuals - 10/17/08
24 Weeks of Pegylated Interferon plus Ribavirin May Be Sufficient for Selected Genotype 1/4 Chronic Hepatitis C Patients with Rapid Response - 10/14/08
Individuals with HCV Genotype 6 Respond Well to Pegylated Interferon plus Ribavirin - 10/14/08
Higher Doses of Pegylated Interferon and Ribavirin May Increase Sustained Response Rates in Hard-to-Treat Patients with Chronic Hepatitis C - 10/10/08
Sustained Virological Response to Pegylated Interferon plus Ribavirin for Chronic Hepatitis C Does Not Always Prevent Hepatocellular Carcinoma - 10/10/08
Genetic Variation Linked to Sustained Response to Pegylated Interferon plus Ribavirin in HALT-C Trial - 9/09/2008
Insulin-sensitizing Agent Pioglitazone (Actos) Did Not Improve Response to Re-treatment with Pegylated Interferon plus Ribavirin - 8/29/2008
Are HIV Positive People More Likely to Relapse after Completion of Hepatitis C Treatment with Pegylated Interferon plus Ribavirin - 8/19/2008
Are HIV Positive People More Likely to Relapse after Completion of Hepatitis C Treatment with Pegylated Interferon plus Ribavirin - 8/19/2008
Eight Weeks of Pegylated Interferon plus Ribavirin for Genotype 2 Chronic HCV Patients with Rapid Virological Response (RVR) - 8/05/2008
Telaprevir plus Pegylated Interferon and Ribavirin Produces Rapid Response and Is Well Tolerated in 28-day Study - 7/22/08
Comparison of the Pegylated Interferons Pegasys and PegIntron for Treatment of Chronic Hepatitis C: Analysis of 16 Randomized Trials - 7/18/08
12- Versus 24-week Treatment with Pegylated Interferon plus Ribavirin for Genotype 2 or 3 Chronic Hepatitis C Patients - 7/11/08
European Commission Approves Shorter 16-week Course of Pegasys plus Ribavirin for Rapid Responders with HCV Genotypes 2 or 3 and Low Viral Load - 7/04/08
Sustained Virological Response to Pegylated Interferon Alfa-2b (PegIntron) with or without Ribavirin Predicts Continued Response through 5 Years - 5/30/08
Clearance of HCV at 5-Year Follow-up for Peginterferon alfa-2b ± Ribavirin Is Predicted by Sustained Virologic Response at 24 Weeks Post-Treatment - 5/20/08
Sustained Virologic Response and Relapse Rates With Peginterferon alfa-2b plus Ribavirin in Clinical Trials Are Comparable to Those in Community-Based Studies - 5/20/08
Rapid Virologic Response to Peginterferon alfa and Ribavirin Treatment of Chronic Hepatitis C Predicts Sustained Virologic Response and Relapse - 5/20/08
Platelet Count Is a Strong Predictor of Sustained Response to Pegylated Interferon/ribavirin in Prior Non-Responders (EPIC 3) - 5/20/08
Amino Acid Substitutions in HCV Core Region Predict Poor Response to Pegylated Interferon/ribavirin in Genotype 1b Patients - 5/20/08
Pegylated Interferon plus Ribavirin Is Effective for Patients with HCV-HBV Coinfection - 5/09/08
Factors Predicting Relapse in Patients with Genotype 2/3 HCV Treated with Pegylated Interferon plus Ribavirin - 5/06/08
Cyclophilin Inhibitor Debio 025 Exhibits Additive Activity against HCV in Combination with Pegylated Interferon - 5/06/08
IDEAL Study Finds Higher End-of-treatment Response with Pegasys, but Lower Relapse Rate with PegIntron - 5/02/08
Milk Thistle (Silibinin) Shows Potent Antiviral Activity in Hepatitis C Patients Who Are Non-responders to Pegylated Interferon/Ribavirin - 5/02/08
R7128 Demonstrates Potent Anti-HCV Activity in Combination with Pegylated Interferon/Ribavirin; Ongoing Trial to be Expanded - 4/29/08
Large HCV RNA Decrease Reduces Adverse Clinical Outcomes, but Pegylated Interferon Maintenance Adds Little Benefit (HALT-C) - 4/29/08
Pegylated Interferon Maintenance Demonstrates Benefits for Hepatitis C Patients with Portal Hypertension - 4/29/08
How Ideal Is the IDEAL Trial?

Intron A + Rebetol
(interferon alfa-2b + ribavirin)

Articles on Intron A + Rebetol
Sustained Response to Interferon-based Therapy Reduces the Likelihood of Type 2 Diabetes - 6/24/08
Selected Hepatitis C Patients with Decompensated Cirrhosis Can Benefit from Interferon-based Therapy prior to Liver Transplantation - 6/10/08
Very Early Response to Interferon-based Therapy for Hepatitis C Is Apparent within the First 24 Hours - 5/30/08
Response to Controlled-release Interferon Alfa-2b (Locteron) in Genotype 1 Hepatitis C Patients - 5/23/08
Significance of Transient HCV Viral Load "Blips" during Interferon-based Therapy for Chronic Hepatitis C - 5/20/08
Clearance of HCV in Children at 5-Year Follow-up Is Predicted by Sustained Virologic Response at 24 Weeks Post Treatment With Interferon alfa-2b Plus Ribavirin - 5/20/08
Symptoms and Response to Interferon plus Ribavirin in Children with Chronic Hepatitis C - 5/20/08
Results from the EPIC3 Program: Platelet Counts Are Strong Predictors of Sustained Viral Response (SVR) in the Re-Treatment of Previous Interferon/Ribavirin Non-Responders (NR) - 5/20/08
Response to Interferon-based Therapy in Hispanic Patients with Chronic Hepatitis C - 5/20/08
Rapid Virological Response Is a Stronger Predictor than HCV Genotype of Sustained Response to Interferon-based Therapy - 5/13/08
HCV Genotypes 2 and 3 Do Not Respond the Same to Interferon-based Treatment - 1/29/08
Interferon-based Therapy Lowers Lymphoma Risk in Hepatitis C Patients - 1/25/08
Growth Hormone Deficiency Common in Hepatitis C Patients, but Improves with Interferon-based Treatment - 1/08/08

Roferon A + Ribavirin
(interferon alfa-2a + ribavirin)

Articles on Intron A + Rebetol
Sustained Response to Interferon-based Therapy Reduces the Likelihood of Type 2 Diabetes - 6/24/08
Significance of Transient HCV Viral Load "Blips" during Interferon-based Therapy for Chronic Hepatitis C - 5/20/08
Symptoms and Response to Interferon plus Ribavirin in Children with Chronic Hepatitis C - 5/20/08
Results from the EPIC3 Program: Platelet Counts Are Strong Predictors of Sustained Viral Response (SVR) in the Re-Treatment of Previous Interferon/Ribavirin Non-Responders (NR)- 5/20/08
HCV Genotypes 2 and 3 Do Not Respond the Same to Interferon-based Treatment - 1/29/08
Interferon-based Therapy Lowers Lymphoma Risk in Hepatitis C Patients - 1/25/08
Growth Hormone Deficiency Common in Hepatitis C Patients, but Improves with Interferon-based Treatment - 1/08/08
Eltrombopag Raises Platelet Counts, Enabling Initiation of Interferon-based Therapy for Hepatitis C - 12/14/07